Her first full week as a co-host was October 24 through October 28, 2011.Tyler is known for being expressive and outspoken on The Talk, especially about African American culture and stereotypes, LGBT rights, and women's rights.Moving into acting, Tyler featured in Friends as Dr.Charlie Wheeler, Joey's and then Ross' girlfriend, in the ninth and tenth seasons.She also made a guest appearance on Kanye West's single "Slow Jamz", which featured Twista and Jamie Foxx.
Starting on July 26, 2011, Tyler started her own weekly podcast, Girl on Guy, where she interviews her favorite celebrity friends and discusses topics guys love. The first weekly installment of Girl on Guy featured guest H.
Tyler's second book, Self-Inflicted Wounds: Heartwarming Tales of Epic Humiliation, debuted in July 2013, later becoming a New York Times bestseller; it was inspired by questions asked of guests on Girl on Guy.
In March 2013, Tyler was confirmed to be the new host of the American version of Whose Line Is It Anyway? She also appears briefly as herself in the video game Watch Dogs and is featured in the music video for the "Weird Al" Yankovic song "Tacky".
She pursued an early interest in comedy at Mc Ateer High School in San Francisco, which had a special program called School of the Arts, now named Ruth Asawa San Francisco School of the Arts.
Tyler's career in television took off in 2001 with jobs as the host of Talk Soup and the reality-dating series The Fifth Wheel, although Talk Soup was canceled the following year and Tyler left The Fifth Wheel in 2002 to pursue other interests.